Interleukin-1-receptor antagonist in the Muckle-Wells syndrome.
نویسندگان
چکیده
2583 2. Lopez-Castilla JD, Cano M, Munoz M, et al. Massive bronchoalveolar aspiration of barium sulfate during a radiologic study of the upper digestive tract. Pediatr Pulmonol 1997;24:126-7. 3. Pracy JP, Montgomery PQ, Reading N. Acute pneumonitis caused by low density barium sulphate aspiration. J Laryngol Otol 1993;107:347-8. 4. Ginai AZ, ten Kate FJ, ten Berg RG, Hoornstra K. Experimental evaluation of various available contrast agents for use in the upper gastrointestinal tract in case of suspected leakage: effects on lungs. Br J Radiol 1984;57:895-901. 5. Gray C, Sivaloganathan S, Simpkins KC. Aspiration of highdensity barium contrast medium causing acute pulmonary inflammation — report of two fatal cases in elderly women with disordered swallowing. Clin Radiol 1989;40:397-400.
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Introduction Muckle-Wells syndrome (MWS) is an inherited autoinflammatory disease (SAID) caused by NLRP3 gene mutations, which results in excessive interleukin-1b (IL-1) secretion. MWS is characterized by recurrent bouts of systemic inflammation, resulting in fever, rash and joint pain. Main complications include sensorineural deafness and amyloidosis. Infertility was mentioned in the first des...
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ورودعنوان ژورنال:
- The New England journal of medicine
دوره 348 25 شماره
صفحات -
تاریخ انتشار 2003